VivaQuant ECG Analysis Services
Regulated studies conducted at VivaQuant, LLC in the USA will be performed in accordance with the U.S. Department of Health and Human Services, Food and Drug Administration, United States Code of Federal Regulations, Title 21 Part 58: Good Laboratory Practice for Nonclinical Laboratory Studies and as accepted by Regulatory Authorities throughout the European Union (OECD Principles of Good Laboratory Practice), Japan (MHLW), and other countries that are signatories to the OECD Mutual Acceptance of Data Agreement.
Streamlined results allow researchers to focus on the science
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VivaQuantTM ECG analysis services are the choice of leading CROs, medical device firms and pharmaceutical companies to provide dependable and accurate reporting of cardiac arrhythmias and intervals from preclinical and clinical ECGs in biomedical research. VivaQuant ECG analysis services leverage VivaQuant's proprietary Rhythm ExpressTM software incorporating patented Multi-Domain Signal Processing (MDSPTM) technology, the new standard for analyzing noisy ECG recordings often encountered in ambulatory research subjects. The efficiency and precision enabled by this unique technology allows us to provide extremely cost-effective services and state-of-the-art accuracy .
Unique Tools -> Differentiated Services
MDSP removes up to 95 percent of noise without distorting the underlying ECG signal, which facilitates highly accurate detection of ECG beats and associated intervals and arrhythmias. The time required for manual confirmation of results is therefore minimized, and we provide a very high beat-to-beat density of intervals, even with relatively poor signal quality. Optional reporting of J to T-peak and T-peak to T-end parameters provides potential improvement in assessment of arrhythmia liability. For studies where arrhythmia liability is of high concern, VivaQuant has partnered with Fossa Consulting, LLC to offer the combined power of QT beat-to-beat and restitution analyses to greatly improve your ability to distinguish between risky and safe drugs (see separate brochure).
Benefits of using VivaQuant services:
- Highest quality comprehensive results at reduced cost.
- Professional graphical and tabular reports.
- Researchers can maintain focus on the science.
- Enhanced interpretation and decision making.
- Accurate measurements result in low variability and excellent statistical power.
- Optimized QRS detection facilitates highly accurate arrhythmia interpretation.
- Ability to evaluate QT during periods of varying autonomic state that prohibit use of QTc (QTbtb).
- Optional JTp and Tpe intervals provide incremental assessment of proarrhythmia liability.
PDF Arrhythmia Report
Service offerings include:
- Evaluation by scientists, physiologists and statisticians with more than 75 years' combined experience with ECG analysis and preclinical research.
- Quantification of arrhythmia incidence and burden and measurement of PR, QRS, RR, QT, QTc and optionally JTp and TpTe intervals.
- Reportable Arrhythmias: Atrial Fibrillation, Bradycardia, Pause, SVE Couplet, SVE Run, Tachycardia, VE Bigeminy, VE Couplet, VE Premature, VE Run, AV Block, Junctional Escape, Atrial Flutter. Also Ventricular Ectopic (VE), Supraventricular Ectopic (SVE), Late, and Dropped Beats.
- Individual and group delta and double delta calculations along with descriptive statistics including standard deviation (SD), standard error of the mean (SEM), and 90 or 95 percent confidence intervals (CI).
- Provision of arrhythmias and beat-to-beat intervals in detailed tabular text format and in PDF reports with numerical and graphical summaries.
- Written report summarizing methods, results, and conclusions and index of numeric and graphics files.
- QA oversight for GLP-compliant studies.
Preclinical Assessment of Multi-channel Block
VivaQuant can assess multi-channel block through the assessment of early repolarization (J to T-peak) and late repolarization (T-peak to T-end) T-wave sub-intervals. This is most appropriately performed on multi-channel ECG recordings as available from standard Holters, the DSI JET system, or implants from TSE that accommodate multiple ECG channels. Multi-channel ECG input is reduced to a composite spatial magnitude (SM) lead projecting all signal energies in the positive direction to enhance signal stability and feature detection. The results can be input into concentration effects modelling like that often used in clinical studies to further refine liability assessment.
 M. Brockway, R. Hamlin. Evaluation of an algorithm for highly automated measurements of QT interval. J Pharmacol Toxicol Methods. 2011; 64:16-24. Read more >